Nebulizer Formulation Services
ARE Labs leads in enhancing respiratory health with expert drug formulation services for therapeutic inhalation delivery via nebulizers. Specializing in a wide range of formulation development and processing, we cater to various inhalation therapies including aqueous suspensions and solutions, ensuring optimized delivery systems for nebulizer applications.
Real-Time Laser Diffraction Particle Sizing: We use state-of-the-art laser diffraction particle sizers for real-time analysis of Active Pharmaceutical Ingredients (API) formulations, ensuring precise particle size distribution.
Cascade Impactors: Our cascade impactor testing provides thorough verification of drug particle size distribution, crucial for consistent and effective aerosol inhalation delivery.
HPLC Verification: Laser diffraction particle sizing does not discriminate between the API and other particles generated during the nebulization process. Through cascade impaction and HPLC analysis we can determine the precise concentration of your API over the entire range of the particle size distribution ensuring your API is being delivered in proper dosages at the optimal particle size.
Intranasal Formulation and Testing
ARE Labs excels in advancing respiratory health with specialized drug formulation services for therapeutic intranasal delivery. Our extensive expertise in formulation development spans various inhalation therapies, including aqueous suspensions and solutions, tailored for effective intranasal or nasal mucosal delivery.
Real-Time Laser Diffraction Particle Sizing: We use state-of-the-art laser diffraction particle sizers for real-time analysis of Active Pharmaceutical Ingredients (API) formulations, ensuring precise particle size distribution.
Cascade Impactors: Our cascade impactor testing provides thorough verification of drug particle size distribution, crucial for consistent and effective aerosol intranasal delivery.
HPLC Verification: Laser diffraction particle sizing does not discriminate between the API and other particles generated during the actuation process. Through cascade impaction and HPLC analysis we can determine the precise concentration of your API over the entire range of the particle size distribution ensuring your formulation is being delivered in proper dosages at the optimal particle size.
Spray Pattern and Plume Geometry: At ARE Labs, we specialize in Spray Pattern and Plume Geometry testing, essential for regulatory compliance of nasal spray products in the U.S. and Europe. This testing is crucial for determining the uniform delivery and bioavailability of the product, impacting its efficacy. The plume’s shape, angle, and duration influence drug deposition in nasal regions or lungs, affecting absorption and effectiveness. We use advanced tools like the Proveris SprayView for automated, high-speed imaging and precise data capture, enabling optimal product performance analysis.
Dry Powder Formulation
At ARE Labs, we are dedicated to advancing respiratory health through specialized drug formulation processing and optimization for therapeutic inhalation delivery. Our expertise in respiratory formulation development is specifically tailored to cater to the unique demands of aerosol inhalation delivery.
Advanced Processing Techniques for Dry Powder Formulations
Cutting-Edge Milling and Drying Processes: We employ advanced techniques like planetary ball milling and jet milling for fine-tuning particle sizes. Our spray drying and encapsulation methods, coupled with cyclone separation techniques, are meticulously executed to optimize the respirable mass of dry powder formulations.
Targeted Drug Deposition: Our processing expertise extends to achieving precise targeting of nasal mucosal/intra-nasal, upper, lower, and deep lung deposition sites, crucial for effective treatment outcomes in various respiratory conditions.cluding dry powder, aqueous suspensions, and solution forms.
Stability and Accelerated Aging
At ARE Labs, we specialize in comprehensive stability and accelerated aging testing services, designed to ensure the long-term efficacy, safety, and reliability of your products. Our state-of-the-art testing facilities provide critical insights into how your products will perform over time, helping you meet regulatory requirements and maintain the highest standards of quality.
Accelerated Aging Testing: Utilizing advanced environmental chambers, we simulate the effects of aging on your products under accelerated conditions. This includes exposure to elevated temperatures, humidity, light, and other stressors to quickly uncover potential degradation or performance issues.
Real-Time Stability Testing: Our real-time stability testing evaluates how your products hold up under normal storage conditions over an extended period. This process is crucial for determining shelf life and ensuring long-term product stability.
Customized Testing Protocols: We tailor our testing protocols to meet the specific needs of your industry, whether it's pharmaceuticals, medical devices, consumer goods, or electronics.
