Intranasal Aerosol Formulation and Testing

Optimize Your Intranasal Drug Delivery with ARE Labs

Intranasal Aerosol Formulation and Testing

Optimize Your Intranasal Drug Delivery with ARE Labs

Intranasal Aerosol Formulation and Testing

Optimize Your Intranasal Drug Delivery with ARE Labs

At ARE Labs, we are at the forefront of advancing respiratory health through our specialized services in drug formulation and optimization for therapeutic intranasal delivery. Our expertise encompasses a broad spectrum of formulation development and processing, catering to various forms of inhalation therapies intended for Intranasal/Nasal Mucosal delivery including aqueous suspensions, and solutions.

At ARE Labs, we are at the forefront of advancing respiratory health through our specialized services in drug formulation and optimization for therapeutic intranasal delivery. Our expertise encompasses a broad spectrum of formulation development and processing, catering to various forms of inhalation therapies intended for Intranasal/Nasal Mucosal delivery including aqueous suspensions, and solutions.

At ARE Labs, we are at the forefront of advancing respiratory health through our specialized services in drug formulation and optimization for therapeutic intranasal delivery. Our expertise encompasses a broad spectrum of formulation development and processing, catering to various forms of inhalation therapies intended for Intranasal/Nasal Mucosal delivery including aqueous suspensions, and solutions.

Advanced Particle Sizing and Verification

Advanced Particle Sizing and Verification

Advanced Particle Sizing and Verification

  • Real-Time Laser Diffraction Particle Sizing: We use state-of-the-art laser diffraction particle sizers for real-time analysis of Active Pharmaceutical Ingredients (API) formulations, ensuring precise particle size distribution.

  • Cascade Impactors: Our cascade impactor testing provides thorough verification of drug particle size distribution, crucial for consistent and effective aerosol intranasal delivery.

  • HPLC Verification: Laser diffraction particle sizing does not discriminate between the API and other particles generated during the actuation process. Through cascade impaction and HPLC analysis we can determine the precise concentration of your API over the entire range of the particle size distribution ensuring your formulation is being delivered in proper dosages at the optimal particle size.

  • Spray Pattern and Plume Geometry: Spray pattern and plume geometry characterization during development is a regulatory requirement for nasal spray products aimed at the US market (with many European developers also including this information in their submissions). Spray pattern data is also required for release testing. The shape, angle and duration of plume is highly influential in the uniform delivery and bioavailability of the product, and therefore product efficacy. For a nasal spray, for example, the shape of the plume and how it disperses will affect where the drug product is deposited in the lungs or nasal regions and this in turn affects absorbance and bioavailability. Our scientists use automated actuation and analysis by instruments such as the Proveris SprayView which incorporates actuation and high-speed imaging to obtain accurate and robust data that enables you to calculate various parameters. 

Comprehensive Services for Aerosol Delivery Devices

Comprehensive Services for Aerosol Delivery Devices

Comprehensive Services for Aerosol Delivery Devices

  • Device Selection and Packaging Options: ARE Labs offers guidance in selecting the most suitable aerosol delivery devices and packaging options, tailored to your specific drug formulation.

  • Characterization Testing for Targeted Delivery: We conduct comprehensive characterization testing to optimize devices for delivering the desired respired dose concentration, ensuring targeted and efficient drug delivery.

Formulations

Formulations

Formulations

ARE Labs has extensive experience with a variety of different intranasal formulations with different API’s, delivery methods and suspension types. Below are some of the formulation services we offer:

  • Dry Powder Nasal Formulations

  • Intranasal Formulations

  • Solid Suspension Formulations

  • Optimization of Existing Formulations

  • Formulation Stability Testing

  • Delivery Efficiency Optimization

  • pH, Viscosity and Porosity Analysis and Adjustments

Your Partner in Pharmaceutical Aerosol Innovation

Your Partner in Pharmaceutical Aerosol Innovation

Your Partner in Pharmaceutical Aerosol Innovation

  • Tailored Solutions: At ARE Labs, we provide personalized solutions to meet the unique challenges of your drug formulation, from initial development to final product optimization.

  • Regulatory Compliance: Our commitment to using FDA-approved materials and rigorous testing methods ensures that your products meet all regulatory standards. We can assist you in getting your formulation to market and perform the FDA 510(k) testing required.

Contact ARE Labs for Advanced Inhalation Therapy Solutions

Discover how ARE Labs can assist in elevating your pharmaceutical products for inhalation therapy. Whether you're developing new formulations or seeking to optimize existing ones, our team is ready to provide the expertise and innovative solutions you need. Contact us today to learn more about our services and how we can contribute to your success in therapeutic inhalation delivery.

Contact ARE Labs for Advanced Inhalation Therapy Solutions

Discover how ARE Labs can assist in elevating your pharmaceutical products for inhalation therapy. Whether you're developing new formulations or seeking to optimize existing ones, our team is ready to provide the expertise and innovative solutions you need. Contact us today to learn more about our services and how we can contribute to your success in therapeutic inhalation delivery.

Contact ARE Labs for Advanced Inhalation Therapy Solutions

Discover how ARE Labs can assist in elevating your pharmaceutical products for inhalation therapy. Whether you're developing new formulations or seeking to optimize existing ones, our team is ready to provide the expertise and innovative solutions you need. Contact us today to learn more about our services and how we can contribute to your success in therapeutic inhalation delivery.

At ARE Labs, we pride ourselves on adhering to the highest standards of regulatory compliance. All our testing services are conducted in strict accordance with FDA guidelines and cGLP (current Good Laboratory Practice) regulations, ensuring our clients receive results that are both reliable and recognized by regulatory bodies.

At ARE Labs, we pride ourselves on adhering to the highest standards of regulatory compliance. All our testing services are conducted in strict accordance with FDA guidelines and cGLP (current Good Laboratory Practice) regulations, ensuring our clients receive results that are both reliable and recognized by regulatory bodies.

At ARE Labs, we pride ourselves on adhering to the highest standards of regulatory compliance. All our testing services are conducted in strict accordance with FDA guidelines and cGLP (current Good Laboratory Practice) regulations, ensuring our clients receive results that are both reliable and recognized by regulatory bodies.