Real-Time Laser Diffraction Particle Sizing: We use state-of-the-art laser diffraction particle sizers for real-time analysis of Active Pharmaceutical Ingredients (API) formulations, ensuring precise particle size distribution.

Cascade Impactors: Our cascade impactor testing provides thorough verification of drug particle size distribution, crucial for consistent and effective aerosol intranasal delivery.

HPLC Verification: Laser diffraction particle sizing does not discriminate between the API and other particles generated during the actuation process. Through cascade impaction and HPLC analysis we can determine the precise concentration of your API over the entire range of the particle size distribution ensuring your formulation is being delivered in proper dosages at the optimal particle size.

Spray Pattern and Plume Geometry: Spray pattern and plume geometry characterization during development is a regulatory requirement for nasal spray products aimed at the US market (with many European developers also including this information in their submissions). Spray pattern data is also required for release testing. The shape, angle and duration of plume is highly influential in the uniform delivery and bioavailability of the product, and therefore product efficacy. For a nasal spray, for example, the shape of the plume and how it disperses will affect where the drug product is deposited in the lungs or nasal regions and this in turn affects absorbance and bioavailability. Our scientists use automated actuation and analysis by instruments such as the Proveris SprayView which incorporates actuation and high-speed imaging to obtain accurate and robust data that enables you to calculate various parameters.